​​​​Classification corneal cross linking procedure

Classification corneal cross linking procedure

The Need

Classification corneal cross linking procedure is helpful to people seeking keratoconus treatment, keratoconus doctors and researchers.

When a person needs to choose a doctor providing the latest keratoconus treatment, it is important to understand what treatment is being offered. Sometimes the cheapest may not be best. It can be confusing with lot of medical jargon. Also each keratoconus doc may claim his unique version is the best.

When researchers and Keratoconus surgeons present data and want to compare results, a scientific classification helps.Further innovation can occur along each arm of the classification system.

          Cornea Collagen Cross linking  or CXL

Cross linking with Riboflavin C3R         Cross linking with Rose Bengal C3RB


  • Epithelium OFF
  • Epithelium on
  • Cornea Channel

This innovative method was first described by Dr.Boxer-Wachler. The epithelium is irritated to break tight junctions to allow riboflavin(chromophore) to pass.


  • 30 min
  •  10min
  • Other

Dextran free formulations may allow faster penetration of riboflavin through the cornea in to the anterior chamber of the eye.


  • 30 min
  • 10 min
  • 6 min

As the power is increased further the time of UV exposure decreases. At 18mw/cm2 it is only 6 minutes. The effectiveness is less than the classical treatment time.


  • Iontophoresis
  • Pulsed

This is a method using ions to transport Riboflavin across an intact epithelium,

Insert table
Classification corneal cross linking procedure

The above Classification corneal cross linking procedure is based on and similar to the one proposed by Dr. Hafezi, Randelmann et al.

Learn about corneal collagen cross linking special cost and insurance coverage. We offer FDA approved Avedro epi off classic Dresden protocol conventional cornea cross linking.

Direct Your Visitors to a Clear Action at the Bottom of the Page