​​​​Keratoconus Screening Clinic United States of America

At Keratoconus Eye Disorder Screening Clinic there is no shortcut to detect early or subclinical keratoconus,. One single parameter as a diagnostic factor is not good enough.We require more than one device to screen for keratoconus eye disorder. Algorithims and predictive models in the hnads of keratoconus expert doctors are the best option. Still predicting whether the keratoconus eye disease will progress and which Keratoconus treatment is best requires expereince and knowledge.Useful predictive  factors are age, keratomety, corneal elevation data, and corneal thickness maps.

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Article Outline

Detection of keratoconus
  1. Topographic Indices
  2. Corneal Pachymetry
  3. Aberrometric Analysis
  4. Corneal Biomechanics
    1. Dynamic Bidirectional Applanation Device
    2. Dynamic Scheimpflug Analyzer
  5. Tomographic Measures Using Optical Coherence Tomography
  6. Algorithms and Predictive Models
  7. Analysis of the Corneal Microstructure
  1. Progression of keratoconus
  2. Conclusion
  3. Disclosures

Keratoconus Eye Disorder Screening Clinic uses Topography

Increased curvature, high astigmatism, superior inferior asymmetry as well as difference between the eyes all are part of KISA index which helps in detection of keratoconus eye disorder. Newer methods like oculare residual index and topographical disparity are helpful. Digital interpretation of placido disk images like where the centers of the rings are located are useful.

Keratoconus Eye Disorder Screening Clinic

Pachymetry map at Keratoconus Eye Disorder Screening Clinic

The central thinning as well as the distribution of thinning can detect early keratoconus. New studies have pointed that pattern stand deviation of epithelium may be more sensitive in detection than even total corneal thickness.These tests need to be repeated to learn if keratoconus is progressing

Higher order aberrations (HOA)

HOA get worse as the disease progresses and may even allow classification of the severity of the disease process. IN real life this translates into difficulty in driving especially at night.

Biomechanical Factors

At our Keratoconus detection centers we know that Corneal hysteresis (CH) and the corneal resistance factor (CRF), are different in keratoconus. We are hoping the accuracy and reliability of these techniques improves int he next few years.

Birefringence of corneal stromal fibers measured using polarization-sensitive OCT is a newer exciting method.

Corneal Microstructure

There is decrease in corneal nerve fibres density, corneal nerve fibre lenght, keratocytes. There is increase in the thickness of the corneal nerves. Confocal microscopy is therefore valuable in detecting keratoconus eye disorder.


This topic is too technical but Keratoconus experts need to be familiar with it.


We know you are concerned whether you or your loved ones may be suffering from Keratoconus. You may want to knwo about cornea cross linking recovery.Our keratoconus experts who specialize in detecting keratoconus conduct exams to find keratoconus in people. Register for our keratoconus webinars.


Based on the article in JCRS

New perspectives on the detection and progression of keratoconus

Antonio Martínez-Abad, MSc, David P. Pin~ero, PhD

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